Microtubule +TIPs at a glance.

نویسندگان

  • Anna Akhmanova
  • Michel O Steinmetz
چکیده

This article is part of a Minifocus on microtubule dynamics. For further reading, please see related articles: ‘Kinesins at a glance’ by Sharyn A. Endow et al., (J. Cell Sci. 123, pp. 3420-3424), ‘Tubulin depolymerization may be an ancient biological motor process’ by J. Richard McIntosh et al. (J. Cell Sci. 123, pp. 3425-3434), ‘Towards a quantitative understanding of mitotic spindle assembly and mechanics’ by Alex Mogilner and Erin Craig (J. Cell Sci. 123, pp. 3435-3445) and ‘Post-translational modifications of microtubules’ by Dorota Wloga and Jacek Gaertig (J. Cell Sci. 123, pp. 3447-3455).

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Plus-End-Tracking Proteins and Their Interactions at Microtubule Ends

Microtubules are cytoskeletal elements that are essential for a large number of intracellular processes, including mitosis, cell differentiation and migration, and vesicle transport. In many cells, the microtubule network is organized in a radial manner, with one end of a microtubule (the minus end) embedded near the nucleus and the other end (the plus end) exploring cytoplasmic space, switchin...

متن کامل

The Microtubule Plus End-Tracking Proteins mal3p and tip1p Cooperate for Cell-End Targeting of Interphase Microtubules

BACKGROUND CLIP-170 and EB1 protein family members localize to growing microtubule tips and link spatial information with the control of microtubule dynamics. It is unknown whether these proteins operate independently or whether their actions are coordinated. In fission yeast the CLIP-170 homolog tip1p is required for targeting of microtubules to cell ends, whereas the role of the EB1 homolog m...

متن کامل

S. pombe Kinesins-8 Promote Both Nucleation and Catastrophe of Microtubules

The kinesins-8 were originally thought to be microtubule depolymerases, but are now emerging as more versatile catalysts of microtubule dynamics. We show here that S. pombe Klp5-436 and Klp6-440 are non-processive plus-end-directed motors whose in vitro velocities on S. pombe microtubules at 7 and 23 nm s(-1) are too slow to keep pace with the growing tips of dynamic interphase microtubules in ...

متن کامل

A Proteome-wide Screen for Mammalian SxIP Motif-Containing Microtubule Plus-End Tracking Proteins

Microtubule plus-end tracking proteins (+TIPs) are structurally and functionally diverse factors that accumulate at the growing microtubule plus-ends, connect them to various cellular structures, and control microtubule dynamics [1, 2]. EB1 and its homologs are +TIPs that can autonomously recognize growing microtubule ends and recruit to them a variety of other proteins. Numerous +TIPs bind to ...

متن کامل

New TIPs for successfully growing microtubules

D ynamic microtubules grow and shrink at their plus ends, and the balance between these two processes is regulated by a host of plus end– tracking proteins (+TIPs). van der Vaart et al. (1) and Li et al. (2) describe two new +TIPs that boost microtubule dynamics in mammalian and Drosophila cells. The EB1 family of +TIPs are the master regulators of microtubule plus ends (3). " They can autonomo...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Journal of cell science

دوره 123 Pt 20  شماره 

صفحات  -

تاریخ انتشار 2010